Oxaliplatin is an antineoplastic substance belonging to the group of platinum based compounds. In combination with 5-fluorouracil (5-FU) and folinic acid (FA), Oxaliplatin is indicated for the adjuvant treatment of stage III (Duke's C) colon cancer after complete resection of primary tumor and the treatment of metastatic colorectal cancer.
Oxaliplatin Medac® 5 mg/ml is available as a powder for solution for infusion in vial sizes of 50 mg, 100 mg and 150 mg.
Dacarbazine is a cell cycle non-specific cytotoxic agent, which is thought to function as an alkylating agent, after undergoing activation in the liver. Dacarbazine is used in the treatment of metastatic melanoma, Hodgkin's lymphoma and soft tissue sarcomas.
Dacarbazine Medac® is available as a powder in vial sizes of 100 mg (packs of 10), 200 mg (packs of 10), 500 mg (single packs) and 1,000 mg (single packs).
Asparaginase is an enzyme derived from cultures of Escherichia coli. Asparaginase is the only enzyme currently used in the treatment of cancer. Asparaginase catalyses the breakdown of asparagine and can inhibit the growth of malignant cells unable to synthesise asparagine. It is postulated that some leukaemic blast cells are unable to synthesise asparagine for their own metabolism, hence asparaginase is mainly used in combination regimens to treat acute lymphoblastic leukaemia.
The induction protocols for the treatment of acute leukaemia utilise asparaginase to achieve asparagine depletion of the plasma over a period of about 21 days. Asparaginase medac has a half-life of approximately 1.24 days which is significantly longer than other asparaginase preparations. This may allow longer treatment intervals with asparaginase medac to achieve the desired asparagine depletion.
Asparaginase medac is available in vial sizes of 5,000 and 10,000 I.U., both in packs of five.
Oncaspar® is a conjugate of active E.coli derived asparaginase and monomethoxypolyethylene glycol. The aim of conjugating the active enzyme is to reduce the elimination (thereby allowing the use of lower doses) and to decrease its immunogenicity (thereby improving tolerability).
Oncaspar® has an in-vivo activity similar to that seen with active l-asparaginase. As a result of pegylation the half-life of the conjugated asparaginase is prolonged to approximately 5.7 days. Studies have shown that the asparagine depletion over the desired time interval can be achieved by one single dose of Oncaspar® rather than repeated doses of active asparaginase.
Oncaspar® is available as a solution in single vials of 3,750 I.U.
Urokinase is indicated for the treatment of peripheral arterial thrombosis as well as acute and subacute deep vein thrombosis. It is also indicated for treatment of acute diagnostically confirmed pulmonary embolism, in particular when associated with unstable haemodynamic status, and in cases of thrombosed arteriovenous shunt.
Urokinase Medac® is available in the following vial sizes:
- Urokinase Medac 10,000 IU
- Urokinase Medac 50,000 IU
- Urokinase Medac 100,000 IU
- Urokinase Medac 250,000 IU
- Urokinase Medac 500,000 IU
- Urokinase Medac 1,000,000 IU
By Biotest AG - Germany
Haemoctin® SDH (Human Factor VIII)
Haemoctin® is a chromatographically purified factor VIII product with a physiological concentration of von Willebrand factor (VWF). The final product has an average specific activity of 100 IU per milligram of protein.
Indications are the prevention and treatment of bleedings in haemophilia A (congenital deficiency of coagulation factor VIII) and acquired factor VIII deficiency. Additionally, it is licensed for the treatment of patients with factor VIII inhibitors.
Haemoctin SDH is available as a powder for solution for injection in vial sizes 250, 500, and 1,000 IU.
Human albumin is obtained from the plasma of healthy donors. It is used for volume replacement when plasma protein has been lost and to stabilise oncotic pressure. Human albumin has the following additional effects:
- Improving wound healing by reducing wound oedema
- Providing protein building blocks in repair processes (wound healing)
- Improving the microcirculation by lowering the viscosity of the blood
- Detoxification on account of toxin-binding properties
- Inhibition of inflammation by binding and inactivating toxic products of inflammation
This natural albumin preparation from Biotest has a number of advantages over synthetic plasma expanders, including hardly any side-effects, a low risk of overdose and circulatory overload and better stabilisation of blood pressure.
Human Albumin Biotest is available as 5 percent and 20 percent solutions. As a five percent solution it is used for iso-oncotic volume replacement with a prolonged action, mainly in the field of acute medicine. Human Albumin 20 % Biotest is used to raise oncotic pressure in acute medicine, but also in internal medicine and surgery.
Intratect® is a polyvalent immunoglobulin G preparation from human plasma for intravenous administration (IVIG). It is highly pure, very well tolerated and has a high standard of safety due to a three-stage process for the inactivation or elimination of viruses.
Its main indications are antibody-deficiency diseases and autoimmune diseases.
Intratect® is obtained from human plasma using state-of-the-art technological processes. Its high purity derives from the two-step process of caution-exchange chromatography. Its very good tolerability is attributable to the removal of unwanted secondary substances from the plasma, and to its formulation as a sugar-free and low-salt isotonic solution, stabilized with the amino acid glycine.
Intratect is available in the following concentrations:
- One vial of 20 ml contains: 1 g
- One vial of 50 ml contains: 2.5 g
- One vial of 100 ml contains: 5 g
- One vial of 200 ml contains: 10 g
By Cook Medical - USA
Transmed Pharma offers the full range, over 700 products, of women’s health line from Cook Medical. Those include products for assisted reproduction, hysteroscopic and laparoscopic surgery, high-risk pregnancy and fetal diagnosis, and biomaterials for pelvic floor reconstruction.
- Ovum Collection
- Embryo Culture
- Embryo Transfer
- Gamete Intra-Fallopian Transfer (GIFT)/Zygote Intra-Fallopian Transfer (ZIFT)
- Intrauterine Insemination (IUI)
- Testicular Aspiration
- MINC Benchtop Incubator
- Hysterosalpingography (HSG)
- Selective Salpingography (SSG)
- Sonohysterography (SHG)
- Fetal Access & Treatment
- Genetic Diagnosis
- Labor & Delivery
Advanced Tissue Repair
- Continence Restoration
- Fistula Repair
- Pelvic Floor Repair
- Pelvic Surgery
By IBSA Institut Biochimique SA, Switzerland
Fostimon (Highly Purified FSH)
Fostimon is a pharmaceutical preparation containing human-derived FSH, i.e. the natural pituitary follicle stimulating hormone. FSH is a hormone used in selected clinical situations, to stimulate follicular development in women, or sperm formation and maturation in men.
Fostimon is manufactured in Switzerland by virtue of a high tech patented process that results in a highly purified preparation with negligible content of contaminating proteins. Due to its high level of purity, Fostimon may be administered subcutaneously
Fostimon is available in vials of 75 or 150 IU and is intended for administration under strict medical control.
Merional (Highly Purified hMG)
Merional is a pharmaceutical preparation containing human menopausal gonadotrophin (hMG), i.e. a balanced mix of the natural follicle follicle stimulating hormone (hFSH) and luteinising hormone (hLH).
The hMG is a hormonal mix used to stimulate follicular development in women, and sperm formation and maturation in men or as a substitution therapy in hypogonadic patients.
Merional should be clearly distinguished from old generation hMGs, which contained FSH together with LH just because of the low purification that did not allow to separate FSH from LH as well as from many other impurities. The new technology of IBSA allows to purify FSH and LH by two separate processes. The two hormones are then mixed together to obtain a very pure hMG to be used any time the benefit of LH stimulation is needed beside plain FSH stimulation (Fostimon).
Due to its level of purity, Merional may be administered subcutaneously. Merional is available in vials of 75 or 150 IU and is intended for administration under strict medical control.
Choriomon (Highly Purified hCG )
Choriomon is a pharmaceutical preparation containing human chorionic gonadotrophin (hCG), i.e. the natural placental hormone.
The hormone hCG is used in a variety of clinical situations including the management of pregnancy miscarriage, the induction of final maturation as conclusion of follicle stimulation cycles and in long-term substitution therapy in hypogonadic men.
Choriomon is manufactured in Switzerland by virtue of a high tech process that results in a highly purified preparation with negligible content of contaminating proteins. Due to its level of purity, Choriomon may be administered subcutaneously. Choriomon is available in vials of 2.000 or 5.000 I.U. and is intended for administration under strict medical control.